解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::An in vitro model of ischemic cerebral stroke [oxygen-glucose deprivation (OGD) for 6 h followed by 24 h reoxygenation (R)] with PC12 cells increases Ca(2+) influx by upregulating native L-type Ca(2+) channels and reactive oxygen species (ROS) generation. This reactive oxygen species generation and increase in intrace...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn300143m
更新日期:2013-02-20 00:00:00
abstract::The dorsal raphe nucleus contains one of the largest groups of serotonergic neurons in the mammalian brain and is the main site of origin of the serotonergic projection to the cerebral cortex. Early electrophysiological studies suggested that serotonergic neurons in this cell group formed a homogeneous cell class. Mor...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章,评审
doi:10.1021/cn300224n
更新日期:2013-01-16 00:00:00
abstract::Relapse to cocaine dependence, even after extended abstinence, involves a number of liability factors including impulsivity (predisposition toward rapid, unplanned reactions to stimuli without regard to negative consequences) and cue reactivity (sensitivity to cues associated with cocaine-taking which can promote coca...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn300072u
更新日期:2013-01-16 00:00:00
abstract::We previously reported on the synthesis of substituted phenyl-4-hydroxy-1-piperidyl indole analogues with nanomolar affinity at D2 dopamine receptors, ranging from 10- to 100-fold selective for D2 compared to the D3 dopamine receptor subtype. More recently, we evaluated a panel of aripiprazole analogues, identifying s...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn300142q
更新日期:2012-12-19 00:00:00
abstract::Amyloid-β (Aβ) is a peptide fragment that is prone to aggregate into large fibrils under physiological conditions. Many techniques have been developed to quickly monitor the transition from a primarily monomeric peptide into fibrils. Here we propose a novel method for both incubating and monitoring changes in Aβ aggre...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn300135n
更新日期:2012-11-21 00:00:00
abstract::Amyloid β (Abeta) peptides in their oligomeric form have been proposed as major toxic species in Alzheimer's disease (AD). There are a limited number of anti-Abeta antibodies specific to oligomeric forms of Abeta compared to the monomeric form, and accurate measurement of oligomeric forms in biological samples, cerebr...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn3001262
更新日期:2012-11-21 00:00:00
abstract::Ionic zinc is found at a high concentration in some glutamatergic vesicles of the mammalian brain. Ionic zinc is also found chelated to macromolecules in the extracellular space, constituting what has been called the "zinc veneer". In this communication we show that the zinc ionophore, pyrithione, can be used to demon...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn300061z
更新日期:2012-10-17 00:00:00
abstract::We propose a tripartite biochemical mechanism for memory. Three physiologic components are involved, namely, the neuron (individual and circuit), the surrounding neural extracellular matrix, and the various trace metals distributed within the matrix. The binding of a metal cation affects a corresponding nanostructure ...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn300097b
更新日期:2012-08-15 00:00:00
abstract::Metabolic adaptation to stress is a crucial yet poorly understood phenomenon, particularly in the central nervous system (CNS). The ability to identify essential metabolic events which predict neuronal fate in response to injury is critical to developing predictive markers of outcome, for interpreting CNS spectroscopi...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn300003r
更新日期:2012-07-18 00:00:00
abstract::The present experiments employed in vivo microdialysis to characterize the effects of commonly used endocannabinoid clearance inhibitors on basal and depolarization-induced alterations in interstitial endocannabinoid levels in the nucleus accumbens of rat brain. Compounds targeting the putative endocannabinoid transpo...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn300036b
更新日期:2012-05-16 00:00:00
abstract::Amyloid-β (Aβ) self-assembly into cross-β amyloid fibrils is implicated in a causative role in Alzheimer's disease pathology. Uncertainties persist regarding the mechanisms of amyloid self-assembly and the role of metastable prefibrillar aggregates. Aβ fibrils feature a sheet-turn-sheet motif in the constituent β-stra...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn2001188
更新日期:2012-03-21 00:00:00
abstract::Herein we present the outcome of a high throughput screening (HTS) campaign-based strategy for the rapid identification and optimization of selective and general chemotypes for both kappa (κ) opioid receptor (KOR) activation and inhibition. In this program, we have developed potent antagonists (IC(50) < 120 nM) or ago...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn200128x
更新日期:2012-03-21 00:00:00
abstract::We recently found that tamoxifen suppresses l-glutamate transport activity of cultured astrocytes. Here, in an attempt to separate the l-glutamate transporter-inhibitory activity from the estrogen receptor-mediated genomic effects, we synthesized several compounds structurally related to tamoxifen. Among them, we iden...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn200091w
更新日期:2012-02-15 00:00:00
abstract::α-Synuclein (α-syn) is a 140-amino acid protein that plays a central role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies. However, the molecular determinants that are responsible for triggering and/or propagating α-syn aggregation and toxicity remain poorly understood. Several studies have...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn200074d
更新日期:2011-11-16 00:00:00
abstract::This Review describes recent activity in the advancement of ligands for the metabotropic glutamate 4 receptor subtype and their potential utility as central nervous system (CNS) therapeutics. Until recently, there was a paucity of compounds with suitable selectivity and druglike properties to elucidate the value of th...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章,评审
doi:10.1021/cn200043e
更新日期:2011-08-17 00:00:00
abstract::Glutamate is the major excitatory transmitter in the mammalian CNS, exerting its effects through both ionotropic and metabotropic glutamate receptors. The metabotropic glutamate receptors (mGlus) belong to family C of the G-protein-coupled receptors (GPCRs). The eight mGlus identified to date are classified into three...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn100099n
更新日期:2011-08-17 00:00:00
abstract::Nowadays there are at present no efficient therapies for spinal cord injury (SCI), and new approaches have to be proposed. Recently, a new regenerative medicine strategy has been suggested using smart biomaterials able to carry and deliver cells and/or drugs in the damaged spinal cord. Among the wide field of emerging...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章,评审
doi:10.1021/cn200030w
更新日期:2011-07-20 00:00:00
abstract::Botulinum neurotoxin (BoNT), the etiological agent that causes the neuroparalytic disease botulism, has become a highly studied drug target in light of the potential abuse of this toxin as a weapon of bioterrorism. In particular, small molecule inhibitors of the light chain metalloprotease of BoNT serotype A have rece...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn200021q
更新日期:2011-06-15 00:00:00
abstract::Biology has inspired solutions to many engineering problems, including chemical sensing. Modern approaches to chemical sensing have been based on the biological principle of combining cross-selective chemical sensors with a pattern recognition engine to identify odors. Here, we review some recent advances made in mimi...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn200027r
更新日期:2011-05-27 00:00:00
abstract::The clinical benzothiophene SERM (BT-SERM), raloxifene, was compared with estrogens in protection of primary rat neurons against oxygen-glucose deprivation (OGD). Structure-activity relationships for neuroprotection were determined for a family of BT-SERMs displaying a spectrum of ERα and ERβ binding affinity and agon...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn100106a
更新日期:2011-05-18 00:00:00
abstract::The kainic acid (KA) receptors belong to the class of glutamate (Glu) receptors in the brain and constitute a promising target for the treatment of neurological and/or psychiatric diseases such as schizophrenia, major depression, and epilepsy. Five KA subtypes have been identified and named GluK1-5. In this article, w...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn100093f
更新日期:2011-02-16 00:00:00
abstract::The finding that acetylcholinesterase (AChE) colocalizes with β-amyloid (Aβ) and promotes and accelerates Aβ aggregation has renewed an intense interest in developing new multifunctional AChE inhibitors as potential disease-modifying drugs for Alzheimer's therapy. To this end, we have developed a new class of selectiv...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn100069c
更新日期:2010-11-17 00:00:00
abstract::Neuronal cytotoxicity observed in Alzheimer's disease (AD) is linked to the aggregation of β-amyloid peptide (Aβ) into toxic forms. Increasing evidence points to oligomeric materials as the neurotoxic species, not Aβ fibrils; disruption or inhibition of Aβ self-assembly into oligomeric or fibrillar forms remains a via...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn100045q
更新日期:2010-09-15 00:00:00
abstract::Dopamine (DA) is a neurotransmitter implicated in multiple functions, including movement, cognition, motivation, and reward. The DA transporter (DAT) is responsible for clearing extracellular DA, thereby terminating DA neurotransmission. Previously, it has been shown that insulin signaling through protein kinase B/Akt...
journal_title:ACS chemical neuroscience
pub_type: 信件
doi:10.1021/cn100031t
更新日期:2010-07-21 00:00:00
abstract::Savella (milnacipran), a selective serotonin and noradrenaline reuptake inhibitor, was approved by the FDA on January 14th, 2009, for the treatment of fibromyalgia. ...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章,评审
doi:10.1021/cn1000233
更新日期:2010-05-19 00:00:00
abstract::Dendritic spines are the postsynaptic sites for the majority of excitatory synapses in the mammalian forebrain. While many spines display great stability, others change shape in a matter of seconds to minutes. These rapid alterations in dendritic spine number and size require tight control of the actin cytoskeleton, t...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn100012x
更新日期:2010-05-19 00:00:00
abstract::Vesicular acetylcholine transporter (VAChT) is a member of the major facilitator superfamily (MFS). It contains conserved sequence motifs originally defined in the bacterial multidrug resistance transporter family of the MFS. Motif C (GSLV(227) A(228)PPFGGIL) is located at the C-terminal end of transmembrane helix 5 (...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn900033s
更新日期:2010-05-19 00:00:00
abstract::Selective potentiators of glutamate response at metabotropic glutamate receptor subtype 5 (mGluR5) have exciting potential for the development of novel treatment strategies for schizophrenia. A total of 1,382 compounds with positive allosteric modulation (PAM) of the mGluR5 glutamate response were identified through h...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn9000389
更新日期:2010-04-21 00:00:00
abstract::The present study was performed to investigate the possible role of protein kinase C (PKC) in morphine tolerance at spinal levels of rats. Intrathecal injection of 10 μg of morphine induced increases in the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation in rats. After intrathecal inject...
journal_title:ACS chemical neuroscience
pub_type: 杂志文章
doi:10.1021/cn900005d
更新日期:2010-02-17 00:00:00